史金铭副教授，硕士生导师，副院长，专业负责人

联系方式：

E-mail: jmshi@nefu.edu.cn

电话：13384664535

地址：黑龙江省哈尔滨市香坊区和兴路26号

99905i银河官方网（新逸夫教学楼）117房间

教育和训练经历:

1997/09－2001/07，吉林大学，生物化学，理学学士

2001/09－2004/07，吉林大学，酶工程，理学硕士

2005/3－2010/03，哈尔滨工业大学，生物技术，工学博士

工作经历：

2010/07－2016/09，99905i银河官方网，99905i银河官方网，讲师

2016/09－至今，99905i银河官方网，99905i银河官方网，副教授

专业特长:

生物化学，表观遗传学，分子生物学

研究经验和研究领域:

主要研究植物小分子化合物的生物活性和抗癌机制。相关成果发表在Phytomedicine、Curr Cancer Drug Targets等期刊上。参加国家自然科学基金面上项目3项，黑龙江省自然科学基金重点项目1项。主持省自然科学基金3项，省教育厅课题1项，中央高校课题2项。

教学情况:

承担本科生课程《生物化学A》、《生物化学实验》和《生化分析技术》；留学生课程《Experimental Techniques of Current Biology》和《Current Progress in Molecular Biology》的部分讲课内容。

承担的主要课题:

1）国家自然科学基金面上项目，SOX7在乳腺癌中调控机制的研究（81472635）2015.01‐2018.12；第二参与人：史金铭。

2）国家自然科学基金面上项目，乳腺癌中YY1调节促癌蛋白活性的机制及其应用价值的研究（81672795）2017.01‐2020.12；第二参与人：史金铭。

3）国家自然科学基金面上项目，乳腺癌中YY1调节促癌蛋白活性的机制及其应用价值的研究（81672795）2017.01-2020.12；第二参与人：史金铭。

4）黑龙江省自然科学基金面上项目：药物诱导低DNA甲基化对植物抗氧化性的影响（C201108）2012.01-2014.12；负责人：史金铭。

5）黑龙江省自然科学基金青年项目：利用小鼠移植瘤模型研究miR-15a/16对乳腺癌中脂肪酸合酶的抑制及其临床应用价值，（QC2016100）2016.07-2019.10；负责人：史金铭。

6）黑龙江省自然科学基金联合引导项目：利用多肽干扰EZH2与YY1的结合抑制乳腺癌的分子机制研究（LH2020H002）；2020.07-2023.07；负责人：史金铭。

主要发表文章:

1. Jinming Shi, Aixin Hao, Qiang Zhang, and Guangchao Sui*. The Role of YY1 in Oncogenesis and Its Potential as a Drug Target in Cancer Therapies. Current Cancer Drug Targets. (2015) 15(2):145-157.

2. Qiang Zhang, Meimei Wan, Jinming Shi, David A. Horita, Lance D. Miller, Timothy E. Kute, Steven J. Kridel, George Kulik, and Guangchao Sui*. Yin Yang 1 Promotes mTORC2-mediated AKT Phosphorylation. J. Mol. Cell. Biol. (2016) 8(3):232-243.

3. Jingxuan Wang, Xiao Zhang, Jinming Shi, Paul Cao, Meimei Wan, Qiang Zhang, Yunxuan Wang, Steven J. Kridel, Wennuan Liu, Jianfeng Xu, Qingyuan Zhang and Guangchao Sui*. Fatty Acid Synthase is a Primary Target of MiR-15a and MiR-16-1 in Breast Cancer. Oncotarget. (2016) 7(48):78566-78576.

4. Na Tian, Jialiang Li, Jinming Shi and Guangchao Sui*. From General Aberrant Alternative Splicing in Cancers and Its Therapeutic Application to the Discovery of an Oncogenic DMTF1 Isoform. (2017) Int. J. Mol. Sci. 18(191):1-20.

5. Yingzhou Li, Xiao Zhang, Yang Gao, Jiming Shi and Guangchao Sui*. G-quadruplexes in the BAP1 promoter positively regulate its expression. Exp. Cell. Res. (2018) 369(1):147-15.

6. Yige Qi, Ting Yan, Lu Chen, Qiang Zhang, Weishu Wang, Xu Han, Dangdang Li, Jinming Shi and Guangchao Sui*. Characterization of YY1 OPB Peptide for Its Anticancer Activity, Current Cancer Drug Targets, (2019) 19(6):504-511.

7. Chen Zhong, Shuang Qiu, Jialiang Li, Jingling Shen, Yuangang Zu, Jinming Shi* and Guangchao Sui*. Ellagic acid synergistically potentiates inhibitory activities of chemotherapeutic agents to human hepatocellular carcinoma. Phytomedicine, (2019) 59:152921.

8. Ting Yan, Bo Zhao, Qiong Wu, Wenmeng Wang, Jinming Shi, Dangdang Li, Daniel B. Stovall and Guangchao Sui*. Characterization of G-quadruplex formation in the ARID1A promoter. Int J Biol Macromol. (2020) 147:750-761.

9. Yunxuan Wang, Ting Yan, Jialiang Li, Wenmeng Wang, Qiong Wu, Jinming Shi, Dangdang Li, Daniel B. Stovall, Qingyuan Zhang* and Guangchao Sui*. The SNAIL1 promoter contains G-quadruplex structures regulating its gene expression and DNA replication. Exp Cell Res. (2020) 394(2):112158.

10. Qiong Wu, Bo Zhao, Guangchao Sui* and Jinming Shi*. Phytochemicals block glucose utilization and lipid synthesis to counteract metabolic reprogramming in cancer cells. Applied Sciences. (2021) 11:1259.

11. Cheng Yi, Guangyue Li, Wenmeng Wang, Yixuan Sun, Yueling Zhang, Chen Zhong, Daniel B. Stovall, Dangdang Li, Jinming Shi* and Guangchao Sui*. Disruption of YY1-EZH2 Interaction Using Synthetic Peptides Inhibits Breast Cancer Development. Cancers. (2021) 13(10):2402.

12. Jialiang Li, Guangyue Li, Yige Qi, Yao Lu, Hao Wang, Ke Shi, Dangdang Li, Jinming Shi, Daniel B. Stovall and Guangchao Sui*. SRSF5 Regulates Alternative Splicing of DMTF1 pre-mRNA through Modulating SF1 Binding. RNA Biology. (2021) 18(sup1):318-336..

13. Bo Zhao, Jinyan Zhao, Mingshuai Lv, Xiaoyan Li, Jinhua Wang, Zhengrong Yue, Jinming Shi, Guocai Zhang* and Guangchao Sui*. Comparative study of structural properties and biological activities of polysaccharides extracted from Chroogomphus rutilus by four different approaches. Int J Biol Macromol. (2021) 188:215-225.

14. Jinhua Wang, Dangdang Li, Bo Zhao, Juhyok Kim, Guangchao Sui*, Jinming Shi*. Small molecule compounds of natural origin target cellular receptors to inhibit cancer development and progression. Int J Mol Sci. (2022) 23(5): 2672.