滕春波教授，博士生导师，99905i银河官方网院长，兼任99905i银河官方网生物学一级科负责人，细胞生物学二级方向负责人，黑龙江省政协委员，黑龙江省细胞生物学学会副理事长，教育部生物学课程教指委委员，中国畜牧兽医学会动物解剖与胚胎分会副理事长，中国畜牧兽医学会生物技术分会理事，中国民主促进会99905i银河官方网支部主委。
联系方式：
E-mail: NEFU_chunbo @163.com
电话：（+86-451-82191784）
地址：黑龙江省哈尔滨市香坊区和兴路26号
工作经历:
1995/07-2003/06中国水产科学院黑龙江水产研究所副研究员
2003/07-2005/06北京大学99905i银河官方网细胞与遗传系博士后
2005/07-2009/0899905i银河官方网副教授
2009/07- 99905i银河官方网教授
2018/11-2019.07美国梅奥医学中心访问学者
专业特长:
细胞生物学，发育生物学，分子生物学。
研究经验和研究领域:
以细胞、类器官、动物为模型，进行分子细胞生物学研究，主要研究方向包括：
（1）胰腺祖细胞增殖分化分子机制，药用植物活性成分治疗糖尿病的细胞和分子基础研究；
（2）微量金属元素调控细胞生命活动分子机理；
教学情况:
近年来承担本科生细胞生物学、发育生物学、现代生物学进展等课程，研究生细胞分子生物学、发育生物学等课程教学工作。
近年主持课题:
1．国家-地方联合基金重点项目U22A20369
2．黑龙江省学科协同创新项目LJGXCG2022-06
3．国家自然科学基金面上项目，32072801
4．黑龙江省重点基金，ZD2017001
5．中央高校基本科研业务费专项资金，2572016EAJ3
6．国家自然科学基金面上项目，31472159
7．国家自然科学基金面上项目，31272520
8．黑龙江省自然科学基金面上项目，C201215
9．哈尔滨市科技创新人才研究专项优秀学科带头人基金，2012RFXXS048
10．中央高校基本科研业务费专项资金项目，DL09CA16
11．国家自然科学基金面上项目，30670304
主要发表文章: (*为通讯作者)
1. Yu W, Wang Y, Shang J, Liu M, Efferth T, Teng CB*. Isoastragaloside I Promotes Pancreatic Ductal Organoids Differentiation into Functional Insulin-Secreting Cells. Phytomedicine, 2022 Jul 20;102:154190.
https://doi.org/10.1016/j.phymed.2022.154190.
2. Liu M, Yu W, Wang Y, Yan B, Shang J, Zhang C, Wu H, Tai S, Jin L, Teng CB*. A chemical molecule promotes Trop2+ biliary duct organoids differentiation into insulin-secreting cells. bioRxiv 2022.03.10.483710
https://doi.org/10.1101/ 2022.03.10.483710.
3. Jin J, Ma M, Shi S, Wang J, Xiao P, Yu HF, Zhang C, Guo Q, Yu Z, Lou Z*, Teng CB*. Copper enhances genotoxic drug resistance via ATOX1 activated DNA damage repair. Cancer Lett. 2022 Jun 28;536:215651.
https://doi.org/10.1016/j.canlet.2022.215651.
4. Wang W, Qiao S, Li G, Cheng J, Yang C, Zhong C, Stovall DB, Shi J, Teng C, Li D*, Sui G*.A histidine cluster determines YY1-compartmentalized coactivators and chromatin elements in phase-separated enhancer clusters.Nucleic Acids Res. 2022 Apr 7:gkac233.
https://doi.org/10.1093/nar/gkac233.
5. Ma M, Qiu B, Jin J, Wang J, Nie Y, Liang Y, Yu Z, Teng CB*. Establishment of a specific in vivo Cu(Ⅰ) reporting system based on metallothionein screening. Metallomics. 2021 Jul 2;13(7):mfab035.
https://doi.org/10.1093/mtomcs/mfab035.
6. Yang L, Kong D, He M, Gong J, Nie Y, Tai S, Teng C-B*: MiR-7 mediates mitochondrial impairment to trigger apoptosis and necroptosis in Rhabdomyosarcoma.Biochim Biophys Acta Mol Cell Res 2020.
https://doi.org/10.1016/j.bbamcr.2020.118826
7. Liu M，Yu W, Jin J, Ma M, An T, Nie Y, Teng C-B*: Copper promotes sheep pancreatic duct organoid growth by activation of an antioxidant protein 1-dependent MEK-ERK pathway.American Journal Of Physiology-Cell Physiology 2020, 318(4):C806-C816.
https://doi.org/10.1152/ajpcell.00509.2019
8.Yu Z, Wang H, Fang Y, Lu L, Li M, Yan B, Nie Y,Teng C*: Molecular chaperone HspB2 inhibited pancreatic cancer cell proliferation via activating p53 downstream gene RPRM, BAI1, and TSAP6. Journal Of Cellular Biochemistry 2020.
https://doi.org/10.1002/jcb.29455
9.Kong D, He M, Yang L, Zhou R, Yan Y-Q, Liang Y,Teng C-B*: MiR-17 and miR-19 cooperatively promote skeletal muscle cell differentiation. Cellular and molecular life sciences : CMLS 2019.
https://doi.org/10.1007/s00018-019-03165-7
10.Yu Z, Wang H, Fang Y, Lu L, Li M, Yan B, Nie Y,Teng C*: Molecular chaperone HspB2 inhibited pancreatic cancer cell proliferation via activating p53 downstream gene RPRM, BAI1, and TSAP6. Journal Of Cellular Biochemistry 2019.
https://doi.org/10.1002/jcb.29455
11.Zhang Z, Zhai W, Liang J, Chen Z, Ma M, Zhao Y, Liang Y, Li X,Teng C-B*: Mutual inhibitions between epidermal growth factor receptor signaling and miR-124a control pancreatic progenitor proliferation. Journal Of Cellular Physiology 2019, 234:12978-12988.
https://doi.org/10.1002/jcp.27967
12.Yu Z, Zhou R, Zhao Y, Pan Y, Liang H, Zhang J-S, Tai S, Jin L,Teng C-B*: Blockage of SLC31A1-dependent copper absorption increases pancreatic cancer cell autophagy to resist cell death. Cell Proliferation 2019, 52.
https://doi.org/10.1111/cpr.12568
13.Yu Z, Yu Z, Chen Z, Yang L, Ma M, Lu S, Wang C,Teng C*, Nie Y*: Zinc chelator TPEN induces pancreatic cancer cell death through causing oxidative stress and inhibiting cell autophagy. Journal Of Cellular Physiology 2019, 234:20648-20661.
https://doi.org/10.1002/jcp.28670
14.Yin W, Yang L, Kong D, Nie Y, Liang Y,Teng C-B*: Guanine-rich RNA binding protein GRSF1 inhibits myoblast differentiation through repressing mitochondrial ROS production. Experimental Cell Research 2019, 381:139-149.
https://doi.org/10.1016/j.yexcr.2019.05.004
15.Yang L, Zhu Y, Kong D, Gong J, Yu W, Liang Y, Nie Y,Teng C-B*: EGF suppresses the expression of miR-124a in pancreatic beta cell lines via ETS2 activation through the MEK and PI3K signaling pathways. International Journal Of Biological Sciences 2019, 15:2561-2575.
https://doi.org/10.7150/ijbs.34985
16.Zhang F, Ma D, Liu T, Liu YH, Guo J, Song J, Wu Q, Pan Y, Zhang Y, Guo C,Teng C, Jin L*: Expansion and Maintenance of CD133-Expressing Pancreatic Ductal Epithelial Cells by Inhibition of Transforming Growth Factor-beta Signaling. Stem Cells And Development 2019, 28:1236-1252.
https://doi.org/10.1089/scd.2019.0087
17.Qi H, Teng M, Liu M, Liu S, Li J, Yu H,Teng C, Huang Z*, Liu H, Shao Q,Uman A, Ding T*, Gao Q*, Guo Z*: Biomass-derived nitrogen-doped carbon quantum dots: highly selective fluorescent probe for detecting Fe3+ ions and tetracyclines. Journal Of Colloid And Interface Science 2019, 539:332-341.
https://doi.org/10.1016/j.jcis.2018.12.047
18.Ma R, Wang Y, Qi H, Shi C, Wei G, Xiao L, Huang Z*, Liu S, Yu H,Teng C,Li H, Murugadoss V, Zhang J, Wang Y, Guo Z*: Nanocomposite sponges of sodium alginate/graphene oxide/polyvinyl alcohol as potential wound dressing: In vitro and in vivo evaluation. Composites Part B-Engineering 2019, 167:396-405.
https://doi.org/10.1016/j.compositesb.2019.03.006
19.Liu J, Cao L, Zhao N, Feng Y, Yu Z, Li Y,Teng C, Hu J, Li T*: miR-338-3p inhibits A549 lung cancer cell proliferation and invasion by targeting AKT and beta-catenin signaling pathways. Molecular Medicine Reports 2019, 20:33-40.
https://doi.org/10.3892/mmr.2019.10215
20.Li X,Teng C, Ma J, Fu N, Wang L, Wen J, Wang T-Y*: miR-19 family: A promising biomarker and therapeutic target in heart, vessels and neurons. Life Sciences 2019, 232.
https://doi.org/10.1016/j.lfs.2019.116651
21.Zhai W, Nie Y,Teng C*: Study of miR-148a Overexpression Inhibiting the Proliferation of Pancreatic Progenitor Cells and Its Mechanism. Chinese Journal of Cell Biology 2018, 40:969-976.
22.Jin J,Teng C*, Li T: Combination therapy versus gemcitabine monotherapy in the treatment of elderly pancreatic cancer: a meta-analysis of randomized controlled trials. Drug Design Development And Therapy 2018, 12:475-480.
https://doi.org/10.2147/DDDT.S156766
23.Zhou R-T, He M, Yu Z, Liang Y, Nie Y, Tai S,Teng C-B*: Baicalein inhibits pancreatic cancer cell proliferation and invasion via suppression of NEDD9 expression and its downstream Akt and ERK signaling pathways. Oncotarget 2017, 8:56351-56363.
https://doi.org/10.18632/oncotarget.16912
24.Zhao Y, Song Y, Yao L, Song G,Teng C*: Circulating microRNAs: Promising Biomarkers Involved in Several Cancers and Other Diseases. DNA And Cell Biology 2017, 36:77-94.
https://doi.org/10.1089/dna.2016.3426
25.Li X, Zhang Z, Li Y, Zhao Y, Zhai W, Yang L, Kong D, Wu C, Chen Z,Teng C-B*: miR-18a counteracts AKT and ERK activation to inhibit the proliferation of pancreatic progenitor cells. Scientific Reports 2017, 7.
https://doi.org/10.1038/srep45002
26.Zhao Y, Wang T, Yao L, Liu B,Teng C, Ouyang H: Classical swine fever virus replicated poorly in cells from MxA transgenic pigs. Bmc Veterinary Research 2016, 12.
https://doi.org/10.1186/s12917-016-0794-5
27.Zhao Y, Wang T, Yu Z, Wang H, Liu B, Wu C,Teng C-B*: Inhibiting cyprinid herpesvirus-3 replication with CRISPR/Cas9. Biotechnology Letters 2016, 38:573-578.
https://doi.org/10.1007/s10529-015-2020-0
28.Li X-Y, Zhai W-J,Teng C-B*: Notch Signaling in Pancreatic Development. International Journal Of Molecular Sciences 2016, 17.
https://doi.org/10.3390/ijms17010048
29.Yang J, Zhou F, Xing R, Lin Y, Han Y,Teng C*, Wang Q: Development of Large-Scale Size-Controlled Adult Pancreatic Progenitor Cell Clusters by an Inkjet-Printing Technique. Acs Applied Materials & Interfaces 2015, 7:11624-11630.
https://doi.org/10.1021/acsami.5b02676
30.Kong D, Zhao Y, Men T,Teng C-B*: Hippo signaling pathway in liver and pancreas: the potential drug target for tumor therapy. Journal Of Drug Targeting 2015, 23:125-133.
https://doi.org/10.3109/1061186X.2014.983522
31.He M,Teng C-B*: Divergence and codon usage bias of Betanodavirus, a neurotropic pathogen in fish. Molecular Phylogenetics And Evolution 2015, 83:137-142.
https://doi.org/10.1016/j.ympev.2014.11.016
32.Zhao Y, Dai Z, Liang Y, Yin M, Ma K, He M, Ouyang H,Teng C-B*: Sequence-specific inhibition of microRNA via CRISPR/CRISPRi system. Scientific Reports 2014, 4.
https://doi.org/10.1038/srep03943
33.Liang Y, He M,Teng C-B*: Evolution of the vesicular stomatitis viruses: Divergence and codon usage bias. Virus Research 2014, 192:46-51.
https://doi.org/10.1016/j.virusres.2014.08.013
34.Li Y,Teng C*: Angiopoietin-like proteins 3, 4 and 8: regulating lipid metabolism and providing new hope for metabolic syndrome. Journal Of Drug Targeting 2014, 22:679-687.
https://doi.org/10.3109/1061186X.2014.928715
35.He M, Yan X-C, Liang Y, Sun X-W,Teng C-B*: Evolution of the viral hemorrhagic septicemia virus: Divergence, selection and origin. Molecular Phylogenetics And Evolution 2014, 77:34-40.
https://doi.org/10.1016/j.ympev.2014.04.002
36.He M, An T-Z,Teng C-B*: Evolution of mammalian and avian bornaviruses. Molecular Phylogenetics And Evolution 2014, 79:385-391.
https://doi.org/10.1016/j.ympev.2014.07.006
37.Zhang Z-W, Men T, Feng R-C, Li Y-C, Zhou D,Teng C-B*: miR-375 Inhibits Proliferation of Mouse Pancreatic Progenitor Cells by Targeting YAP1. Cellular Physiology And Biochemistry 2013, 32:1808-1817.
https://doi.org/10.1159/000356614
38.Men T, Piao S-H,Teng C-B*: Regulation of differentiation of mesenchymal stem cells by the Hippo pathway effectors TAZ/YAP. Yi chuan = Hereditas 2013, 35:1283-1290.
39.Li D, Peng S-y, Zhang Z-w, Feng R-c, Li L, Liang J, Tai S,Teng C-B*: Complete disassociation of adult pancreas into viable single cells through cold trypsin-EDTA digestion. Journal Of Zhejiang University-Science B 2013, 14:596-603.
https://doi.org/10.1631/jzus.B1200226
40.He M, Ding N-Z, He C-Q, Yan X-C,Teng C-B*: Dating the divergence of the infectious hematopoietic necrosis virus. Infection Genetics And Evolution 2013, 18:145-150.
https://doi.org/10.1016/j.meegid.2013.05.014
41.Feng R, Lang Y, Liang Y, Wu Y,Teng C*: Identification of marker molecules for negative screening of pancreatic stem cells. Chinese Journal of Tissue Engineering Research 2013, 17:1785-1792.
42.Yang Y, Ding L, An Y, Zhang Z-w, Lang Y, Tai S, Guo F,Teng C-B*: MiR-18a regulates expression of the pancreatic transcription factor Ptf1a in pancreatic progenitor and acinar cells. Febs Letters 2012, 586:422-427.
https://doi.org/10.1016/j.febslet.2012.01.015
43.Yan X, Ding L, Li Y, Zhang X, Liang Y, Sun X,Teng C-B*: Identification and Profiling of MicroRNAs from Skeletal Muscle of the Common Carp. Plos One 2012, 7.
https://doi.org/10.1371/journal.pone.0030925
44.Zhang Z-W, Zhang L-Q, Ding L, Wang F, Sun Y-J, An Y, Zhao Y, Li Y-H,Teng C-B*: MicroRNA-19b downregulates insulin 1 through targeting transcription factor NeuroD1. Febs Letters 2011, 585:2592-2598.
https://doi.org/10.1016/j.febslet.2011.06.039
45. An Y, Yang Y-K, Gao F, Zhu K-Y, Mu T-W,Teng C-B*: Identification of MicroRNAs Regulating Ptf1a Expression in Mouse Pancreas Development. Progress In Biochemistry And Biophysics 2009, 36:1607-1612.
https://doi.org/10.3724/SP.J.1206.2009.00298
46.Teng CB, Guo YS, Zhang H, Zhang H, Ding MX* and Deng HK*. Identification and characterization of LRCs in mouse pancreas.Differentiation.2007, 75(8):702-12.
https://10.1111/j.1432-0436.2007.00170.x.
47. Lian G, Wang C, Teng CB, Zhang C, Du L, Zhong Q, Miao C, Ding M*, and Deng H*. Failure of hepatocyte marker-expressing hematopoietic progenitor cells to efficiently convert into hepatocytes in vitro.Exp Hematol. 2006, 34(3):348-58
https://10.1016/j.exphem.2005.12.004
发明专利：
1．滕春波，李丹。一种新型高效小鼠胰腺单细胞悬液的制备方法申请专利号：200910073257.9，申请日期：2009.11.25；授权公告日：2011.5.4； 发明专利号：ZL200910073257.9
2.滕春波,王法,张立新。一种小鼠胰腺干/祖细胞的离体筛选扩增技术申请专利号：201010032456.8,申请日期：2010.1.13；授权公告日：2012.6.27；发明专利号：ZL201010032456.8
